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Belal Hanafy · PhD

Tools

A published model you can turn the dials on.

Papers describe models. This one ships with its model attached, so you can change a formulation and watch the prediction move, without installing anything.

The PRELIVE profiler: prediction traces for liver radiance against ionisable lipid, DSPC, cholesterol and DMG-PEG content, particle size and lipid choice, with tabs for eight tissues across the top.
Open access · CC BY 4.0Runs in your browser

PRELIVE

Predicting in-vivo functional delivery of lipid nanoparticles from composition

What you change

Ionisable lipid
% mol, plus a choice of five ionisable lipid chemistries
DSPC
% mol, the helper phospholipid
Cholesterol
% mol
DMG-PEG
% mol, the PEGylated lipid controlling circulation
Particle size
nm, measured by dynamic light scattering

What it predicts

Functional mRNA delivery, reported as log radiance from a luciferase reporter, in each of eight compartments:

  • Liver
  • Spleen
  • Kidney
  • Bone marrow
  • Lung
  • Heart
  • Brain
  • Whole blood
Open the profiler Read the paper

Never used a profiler?

Each small panel shows one input. The trace inside it is the model’s prediction as that single input varies, holding the others where you have set them. Drag the vertical line to change a value; every trace redraws, because the inputs interact.

A steep trace means the prediction is sensitive to that input. A flat one means it barely matters, which is often the more useful finding.

Why it is here

A model that lives only in a figure cannot be interrogated. Making it interactive lets a reader test the formulation they actually care about, rather than the ones we happened to plot.

It also does the thing the paper argues for: answering a question computationally, in seconds, that would otherwise have taken an in-vivo study.